Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia.

Autor: Zapata-Arriaza E; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain., Mancha F; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain., Bustamante A; Neurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain., Moniche F; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Department of Neurology, Hospital Universitario Virgen del Rocío, Seville, Spain., Pardo-Galiana B; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Department of Neurology, Hospital Universitario Virgen del Rocío, Seville, Spain., Serrano-Gotarredona P; Radiology Department, University Hospital Virgen del Rocio, Seville, Spain., Navarro-Herrero S; Radiology Department, University Hospital Virgen del Rocio, Seville, Spain., Pallisa E; Department of Radiology, Vall d'Hebron University Hospital, Barcelona, Spain., Faura J; Neurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain., Vega-Salvatierra Á; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain., Penalba A; Neurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain., Escudero-Martínez I; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.; Department of Neurology, Hospital Universitario Virgen del Rocío, Seville, Spain., Ramos-Herrero VD; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain., Azurmendi L; Department of Human Protein Sciences, University of Geneva, Geneve, Switzerland., Charles Sanchez J; Department of Human Protein Sciences, University of Geneva, Geneve, Switzerland., Montaner J; Stroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2019 Sep; Vol. 6 (9), pp. 1882-1887. Date of Electronic Publication: 2019 Jul 31.
DOI: 10.1002/acn3.50849
Abstrakt: To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.
(© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.)
Databáze: MEDLINE
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