Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.

Autor: Igonina TN; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia., Ragaeva DS; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia., Petrova OM; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia.; Department of Natural Sciences, Novosibirsk State University , Novosibirsk , Russia., Rozkova IN; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia., Brusentsev EY; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia., Amstislavsky SY; Sector of Cryopreservation and Reproductive Technologies, Institute of Cytology and Genetics , Novosibirsk , Russia.
Jazyk: angličtina
Zdroj: Hypertension in pregnancy [Hypertens Pregnancy] 2019 Nov; Vol. 38 (4), pp. 208-216. Date of Electronic Publication: 2019 Jul 31.
DOI: 10.1080/10641955.2019.1647232
Abstrakt: Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female offspring. When ET was accompanied with in vitro culture in R1ECM, not only the female offspring, but also males demonstrated alleviation of hypertension. Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring.
Databáze: MEDLINE
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