Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [ 11 C]PBR28 HRRT PET study.

Autor: Tuisku J; Turku PET Centre, University of Turku, Turku, Finland. joupes@utu.fi.; Turku PET Centre, c/o Turku University Hospital, Po Box 52, 20521, Turku, Finland. joupes@utu.fi., Plavén-Sigray P; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden., Gaiser EC; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.; Department of Psychiatry, Yale University, New Haven, CT, 06511, USA., Airas L; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Al-Abdulrasul H; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Brück A; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Carson RE; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA., Chen MK; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA., Cosgrove KP; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.; Department of Psychiatry, Yale University, New Haven, CT, 06511, USA., Ekblad L; Turku PET Centre, University of Turku, Turku, Finland., Esterlis I; Department of Psychiatry, Yale University, New Haven, CT, 06511, USA., Farde L; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden.; PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Solna, Sweden., Forsberg A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden., Halldin C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden., Helin S; Turku PET Centre, University of Turku, Turku, Finland., Kosek E; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Lekander M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Stress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden., Lindgren N; Turku PET Centre, University of Turku, Turku, Finland., Marjamäki P; Turku PET Centre, University of Turku, Turku, Finland., Rissanen E; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Sucksdorff M; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Varrone A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden.; Stress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden., Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J; Turku PET Centre, University of Turku, Turku, Finland.; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland., Matuskey D; PET Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, 06520, USA.; Department of Psychiatry, Yale University, New Haven, CT, 06511, USA., Cervenka S; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm County, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 Oct; Vol. 46 (11), pp. 2329-2338. Date of Electronic Publication: 2019 Jul 30.
DOI: 10.1007/s00259-019-04403-7
Abstrakt: Purpose: The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [ 11 C]PBR28.
Methods: [ 11 C]PBR28 data from 140 healthy volunteers (72 males and 68 females; N = 78 with HAB and N = 62 MAB genotype; age range 19-80 years; BMI range 17.6-36.9) were acquired with High Resolution Research Tomograph at three centres: Karolinska Institutet (N = 53), Turku PET centre (N = 62) and Yale University PET Center (N = 25). The total volume of distribution (V T ) was estimated in global grey matter, frontal, temporal, occipital and parietal cortices, hippocampus and thalamus using multilinear analysis 1. The effects of age, BMI and sex on TSPO availability were investigated using linear mixed effects model, with TSPO genotype and PET centre specified as random intercepts.
Results: There were significant positive correlations between age and V T in the frontal and temporal cortex. BMI showed a significant negative correlation with V T in all regions. Additionally, significant differences between males and females were observed in all regions, with females showing higher V T . A subgroup analysis revealed a positive correlation between V T and age in all regions in male subjects, whereas age showed no effect on TSPO levels in female subjects.
Conclusion: These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje