Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots.

Autor:	Benyettou F; Program in Chemistry , New York University Abu Dhabi , UAE . Email: Ali.trabolsi@nyu.edu., Prakasam T; Program in Chemistry , New York University Abu Dhabi , UAE . Email: Ali.trabolsi@nyu.edu., Ramdas Nair A; Program in Biology , New York University Abu Dhabi , UAE., Witzel II; Core Technology Platform , New York University Abu Dhabi , UAE., Alhashimi M; Program in Chemistry , New York University Abu Dhabi , UAE . Email: Ali.trabolsi@nyu.edu., Skorjanc T; Program in Chemistry , New York University Abu Dhabi , UAE . Email: Ali.trabolsi@nyu.edu., Olsen JC; Department of Chemistry , University of Rochester , Rochester , New York , USA., Sadler KC; Program in Biology , New York University Abu Dhabi , UAE., Trabolsi A; Program in Chemistry , New York University Abu Dhabi , UAE . Email: Ali.trabolsi@nyu.edu.
Jazyk:	angličtina
Zdroj:	Chemical science [Chem Sci] 2019 May 22; Vol. 10 (23), pp. 5884-5892. Date of Electronic Publication: 2019 May 22 (Print Publication: 2019).
DOI:	10.1039/c9sc01218d
Abstrakt:	A set of metal-organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells--including those resistant to cisplatin--and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.
Databáze:	MEDLINE
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