Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Autor: Giotis ES; Section of Virology, Department of Medicine, Imperial College London, London, UK. e.giotis@imperial.ac.uk., Carnell G; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.; Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Young EF; Department of Surgery, Hackensack University Medical Center, Hackensack, NJ, USA.; Bioelectronic Systems Lab, Columbia University, New York, NY, USA., Ghanny S; The Genomics Center, New Jersey Medical School, Rutgers University, Newark, NJ, USA., Soteropoulos P; The Genomics Center, New Jersey Medical School, Rutgers University, Newark, NJ, USA., Wang LF; Programme in Emerging Infectious Disease, Duke-NUS Medical School, Singapore, Singapore., Barclay WS; Section of Virology, Department of Medicine, Imperial College London, London, UK., Skinner MA; Section of Virology, Department of Medicine, Imperial College London, London, UK., Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2035-2038. Date of Electronic Publication: 2019 Jul 29.
DOI: 10.1038/s41564-019-0517-3
Abstrakt: Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.
Databáze: MEDLINE