Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil.

Autor:	Carvalho LVB; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil. leandro.carvalho@ensp.fiocruz.br., Hacon SS; Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Vega CM; Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil.; Centro de Innovaccion Cientifica Amazonica (CINCIA), Jr. Cajamarca c 1 s/n, Puerto Candamo, Puerto Maldonado, Madre de Dios, PERU - Wake Forest University, 1834 Wake Forest Rd, Winston-Salem, NC 27109, USA., Vieira JA; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Larentis AL; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Mattos RCOC; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Valente D; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Costa-Amaral IC; Toxicology Laboratory, Center for Studies of Worker's Health and Human Ecology (CESTEH), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Mourão DS; Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Silva GP; Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil., Oliveira BFA; Department of Endemics Samuel Pessoa (DENSP), National School of Public Health Sergio Arouca (ENSP), Oswaldo Cruz Foundation (Fiocruz), Leopoldo Bulhões Street, 1480, Manguinhos, Rio de Janeiro-RJ, CEP 21041-210, Brazil.
Jazyk:	angličtina
Zdroj:	International journal of environmental research and public health [Int J Environ Res Public Health] 2019 Jul 27; Vol. 16 (15). Date of Electronic Publication: 2019 Jul 27.
DOI:	10.3390/ijerph16152682
Abstrakt:	Oxidative stress can be induced by mercury (Hg) exposure, including through fish consumption (diet), leading to health risks. The objective of this study was to evaluate the association between oxidative stress biomarkers and dietary Hg exposure levels in riverine children and adoluiaescents at Madeira River (RO/Brazil). Population from three riverine local communities presenting different fish consumption frequencies was sampled. Hg was determined in blood (ICP-MS) and glutathione (GSH); glutathione S-transferases (GST) and malondialdehyde (MDA) were determined in serum (spectrophotometry). Statistical analyses were performed using parametric and non-parametric tests. Multiple linear regression models and generalized additives models were also used to estimate the relationships between oxidative stress biomarkers and blood Hg. The juvenile riverine population from Cuniã RESEX presented the highest levels of oxidative stress and Hg levels in blood (GST = 27.2 (4.93) U/L, MDA = 1.69 (0.27) µmol/L, Hg = 20.6 (18.0) µg/L). This population also presented the highest frequency of fish consumption. The positive relation between Hg and GST and MDA, adjusted for individual characteristics, suggests an oxidative effect. This study shows the importance of oxidative stress biomarkers in the evaluation of dietary Hg exposure since initial and reversible metabolic changes were observed, enriching health risk assessments.
Databáze:	MEDLINE
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