Molecular epidemiology of toxigenic Clostridioides difficile isolates from hospitalized patients and the hospital environment in Dhaka, Bangladesh.

Autor: Sofjan AK; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA. Electronic address: aksofjan@uh.edu., Islam MA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh; Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, 99164, USA., Halder K; Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh., Kabir ND; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh., Saleh AA; Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, 1000, Bangladesh., Miranda J; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA., Lancaster C; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA., Begum K; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA., Alam MJ; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA., Garey KW; University of Houston College of Pharmacy, 4849 Calhound Road, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Anaerobe [Anaerobe] 2020 Feb; Vol. 61, pp. 102081. Date of Electronic Publication: 2019 Jul 26.
DOI: 10.1016/j.anaerobe.2019.102081
Abstrakt: Epidemiology of Clostridioides difficile (syn. Clostridium difficile) infection (CDI) in Bangladesh is poorly understood. This study assessed the epidemiology of CDI in hospitalized patients and hospital environmental contamination of toxigenic C. difficile at two large urban Bangladesh hospitals. This 12-month prospective observational cohort study collected stool samples from adults with diarrhea and recent antimicrobial exposure during 2017. Environmental samples were collected by swabbing surfaces of hospital common areas. Samples underwent toxigenic culture. C. difficile isolates were tested for toxins A and B and PCR-ribotyped. Of 208 stool samples, 18 (8.7%) were positive for toxigenic C. difficile. Of 400 environmental samples, 45 (11%) were positive for toxigenic C. difficile. Ribotypes present in ≥10% of stool isolates were 017 (38%), 053-163 (13%), and a novel ribotype (FP435 [13%]). Common ribotypes in environmental isolates were 017 (22%), 053-163 (11%), 106 (24%). This is the first report describing current epidemiology of CDI in at risk hospitalized adult patients in Bangladesh.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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