Anal prevalence of HPV in women with pre-malignant lesion or cancer in the cervix and anal canal simultaneously: cross-sectional study.

Autor: Heráclio SA; Department of Lower Genital Tract Pathology, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil., de Souza ASR; Department of Fetal Medicine and Ultrasonography, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil., Silveira RK; Department of Coloproctology, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil., Torres LC; Translational Health Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil., Nunes MJG; Keizo Asami Laboratory of Immunopathology, Federal University of Pernambuco, Recife, PE, Brazil., Amorim MMR; Department of Women's Health, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2019 Nov; Vol. 147 (2), pp. 225-232. Date of Electronic Publication: 2019 Aug 12.
DOI: 10.1002/ijgo.12933
Abstrakt: Objective: To determine the prevalence of anal HPV genotypes and associated factors in women with pre-malignant lesion or cancer in the cervix and anal canal.
Methods: A prospective, cross-sectional study analyzed DNA samples taken from women with cervical pre-malignant lesions or cancer to identify anal HPV by polymerase chain reaction (PCR). The prevalence of high-risk HPV (HR-HPV) in women with intraepithelial neoplasia and anal cancer was calculated; sociodemographic and clinical risk factors were identified using multivariate analysis.
Results: A total of 152 patients were included (mean age 37.8 ± 10.01 years), of whom 101 (66.4%) had anal HR-HPV. Fourteen different anal HPV types were identified. HPV 16 and 18 were found in 30 (52.6%) anal high-grade squamous intraepithelial lesions (HSIL), and HPV 31 and 33 in 21 (36.8%) lesions. In the logistic regression analysis, the factors that remained associated with HR-HPV types were: an anal histopathology report of HSIL or invasive carcinoma (odds ratio [OR] 8.96, 95% confidence interval [CI] 3.40-23.57; P<0.0001) and alcohol consumption (OR 2.20, 95% CI 1.01-4.80; P=0.04).
Conclusion: Prevalence of HR-HPV is high in the anal canal of women with cervical and anal pre-malignant lesions simultaneously or cancer of the cervix and/or anal canal. HPV 16, 31, 33, and 18 were the four major genotypes identified.
(© 2019 International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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