Atypical Clinical Manifestations of Cerebral Amyloid Angiopathy.

Autor: Akers C; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA., Acosta LMY; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA., Considine C; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA., Claassen D; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA., Kirshner H; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA., Schrag M; Department of Neurology, Vanderbilt University Medical Center, Medical Research Building III, 465 21st Avenue S, Suite 6160 (Office 6158C), Nashville, TN, 37240, USA. matthew.schrag@vanderbilt.edu.
Jazyk: angličtina
Zdroj: Current neurology and neuroscience reports [Curr Neurol Neurosci Rep] 2019 Jul 27; Vol. 19 (9), pp. 64. Date of Electronic Publication: 2019 Jul 27.
DOI: 10.1007/s11910-019-0981-4
Abstrakt: Purpose: Cerebral amyloid angiopathy is a vasculopathy caused by β-amyloid deposition in cerebral arterioles and capillaries. It is closely linked to Alzheimer's disease and predisposes elderly patients to intracerebral hemorrhage, transient focal neurological episodes, and cognitive impairment. Because of a predilection for symptomatic hemorrhage, particularly in the frontal lobes, cerebral amyloid angiopathy may also cause a dysexecutive syndrome.
Recent Findings: In this case series, we describe presentations of classic clinical dementia syndromes which are not are widely thought to be associated with cerebral amyloid angiopathy, namely logopenic variant primary progressive aphasia (n = 3), normal pressure hydrocephalus (n = 3), and Lewy body dementia (n = 2). In every case, after a clinical diagnosis was established, neuroimaging, brain biopsy, and/or autopsy confirmed the presence of cerebral amyloid angiopathy. Cerebral amyloid angiopathy has significant clinical implications, and its ability to mimic and/or contribute to other clinical dementia syndromes can complicate its diagnosis. This series of cases broadens the range of clinical scenarios associated with cerebral amyloid angiopathy.
Databáze: MEDLINE
Externí odkaz: