Circadian and circannual timescales interact to generate seasonal changes in immune function.

Autor: Onishi KG; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States. Electronic address: kgonishi@uchicago.edu., Maneval AC; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Cable EC; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Tuohy MC; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Scasny AJ; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Sterina E; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Love JA; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Riggle JP; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Malamut LK; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Mukerji A; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Novo JS; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Appah-Sampong A; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Gary JB; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States., Prendergast BJ; Department of Psychology and Institute for Mind and Biology, University of Chicago, Chicago, IL 60637, United States; Committee on Neurobiology, University of Chicago, Chicago, IL 60637, United States; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637, United States.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2020 Jan; Vol. 83, pp. 33-43. Date of Electronic Publication: 2019 Jul 24.
DOI: 10.1016/j.bbi.2019.07.024
Abstrakt: Annual changes in day length enhance or suppress diverse aspects of immune function, giving rise to seasonal cycles of illness and mortality. The daily light-dark cycle also entrains circadian rhythms in immunity. Most published reports on immunological seasonality rely on measurements or interventions performed only at one point in the day. Because there can be no perfect matching of circadian phase across photoperiods of different duration, the manner in which these timescales interact to affect immunity is not understood. We examined whether photoperiodic changes in immune function reflect phenotypic changes that persist throughout the daily cycle, or merely reflect photoperiodic shifts in the circadian phase alignment of immunological rhythms. Diurnal rhythms in blood leukocyte trafficking, infection induced sickness responses, and delayed-type hypersensitivity skin inflammatory responses were examined at high-frequency sampling intervals (every 3 h) in Siberian hamsters (Phodopus sungorus) following immunological adaptation to summer or winter photoperiods. Photoperiod profoundly enhanced or suppressed immune function, in a trait-specific manner, and we were unable to identify a phase alignment of diurnal waveforms which eliminated these enhancing and suppressing effects of photoperiod. These results support the hypothesis that seasonal timescales affect immunity via mechanisms independent of circadian entrainment of the immunological circadian waveform.
(Copyright © 2019. Published by Elsevier Inc.)
Databáze: MEDLINE
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