Experimental Evaluation of the Properties of 3D Porous Bone Substitute Based on Calcium Phosphate on the Model of Monocortical Diaphysial Femur Defect in Rats.

Autor: Dubrov VE; Faculty of Fundamental Medicine, Moscow, Russia. vduort@gmail.com., Klimashina ES; Faculty of Material Sciences, Moscow, Russia.; Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia., Shcherbakov IM; Faculty of Fundamental Medicine, Moscow, Russia., Shipunov GA; Faculty of Fundamental Medicine, Moscow, Russia., Putlyaev VI; Faculty of Material Sciences, Moscow, Russia.; Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia., Evdokimov PV; Faculty of Material Sciences, Moscow, Russia.; Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia., Tikhonov AA; Faculty of Material Sciences, Moscow, Russia., Zyuzin DA; Faculty of Fundamental Medicine, Moscow, Russia., Danilova NV; Faculty of Fundamental Medicine, Moscow, Russia., Mal'kov PG; Faculty of Fundamental Medicine, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Jul; Vol. 167 (3), pp. 400-403. Date of Electronic Publication: 2019 Jul 26.
DOI: 10.1007/s10517-019-04536-7
Abstrakt: A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. One femur fracture with fixator migration was recorded after implantation of the studied material and the reference chronOS synthetic material. The studied material demonstrated better osteoconductive properties then traditional osteoplastic material, which was seen from greater number of bone trabeculae and their area in the defect area.
Databáze: MEDLINE
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