Cancer stem cells in breast and prostate: Fact or fiction?
| Autor: | Sampayo RG; Department of Chemical and Biomolecular Engineering, University of California at Berkeley, Berkeley, CA, United States., Bissell MJ; Division of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA, United States. Electronic address: mjbissell@lbl.gov. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in cancer research [Adv Cancer Res] 2019; Vol. 144, pp. 315-341. Date of Electronic Publication: 2019 Jun 13. |
| DOI: | 10.1016/bs.acr.2019.03.010 |
| Abstrakt: | Since the introduction of the cancer stem cell (CSC) hypothesis, accumulating evidence shows that most cancers present stem-like niches. However, therapies aimed at targeting this niche have not been as successful as expected. New evidence regarding CSCs hierarchy, similarities with normal tissue stem cells and cell plasticity might be key in understanding their role in cancer biology and how to efficiently eliminate them. In this Chapter, we discuss what is known in breast and prostate CSCs from their initial discoveries to the current therapeutic efforts in the field. Future challenges towards better CSC identification and isolation strategies will be key to shed light into how CSCs could accurately be targeted in combination to traditional therapies to ultimately prolong patient survival. (© 2019 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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