Blood arsenic levels and the risk of familial breast cancer in Poland.

Autor: Marciniak W; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Derkacz R; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Muszyńska M; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Baszuk P; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Gronwald J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Huzarski T; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland.; Department of Clinical Genetics and Pathology, University of Zielona Góra, Zielona Góra, Poland., Cybulski C; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Falco M; Radiation Oncology Department, West Pomeranian Oncology Center, Szczecin, Poland., Dębniak T; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland., Lener M; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Oszurek O; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Pullella K; Women's College Research Institute, Toronto, Ontario, Canada., Kotsopoulos J; Women's College Research Institute, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Sun P; Women's College Research Institute, Toronto, Ontario, Canada., Narod SA; Women's College Research Institute, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Lubiński J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Read-Gene SA, Grzepnica, Poland.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2020 May 15; Vol. 146 (10), pp. 2721-2727. Date of Electronic Publication: 2019 Aug 26.
DOI: 10.1002/ijc.32595
Abstrakt: Arsenic is recognized as a potent carcinogen at high concentrations, but the relationship between environmental arsenic and breast cancer risk has not well been studied. Most research has focused on the effect of arsenic in populations with high endemic exposure, and not in populations with arsenic levels within normal limits. We sought to determine if blood arsenic levels predict the risk of breast and other cancers risk among women in northern Poland. The cohort consisted of 1,702 healthy women, aged 40 and above, identified between 2010 and 2017. Blood arsenic level was determined by inductively coupled plasma mass spectrometry. After an average of 4.5 years of follow-up (range 0.7-7.3 years), there were 110 incident cases of cancer diagnosed in the cohort, including 68 cases of breast cancer. Women in the highest quartile of arsenic had a highly significant 13-fold increased risk of developing breast cancer, compared to women in the lowest quartile (hazard ratio [HR] = 13.2; 95% confidence interval [CI] 4.02-43.0). Results were similar for arsenic and all incident cancers (HR quartile 4 vs. quartile 1 = 13.3; 95% CI 4.78-37.0). If confirmed, our study suggests that the blood arsenic level may be a useful predictive marker of cancer risk in women.
(© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
Databáze: MEDLINE
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