Effects of Genital Nerve Stimulation Amplitude on Bladder Capacity in Spinal Cord Injured Subjects.

Autor: Yeh SD; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Lin BS; Department of Computer Science and Information Engineering, National Taipei University, New Taipei City, Taiwan., Chen SC; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan., Chen CH; School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.; Department of Orthopedics, Taipei Medical University - Shuang Ho Hospital, Taiwan.; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Gustafson KJ; Louis Stokes Cleveland VAMC, Cleveland, OH, USA.; Cleveland FES Center, Cleveland, OH, USA.; Departments of Biomedical Engineering & Urology, Case Western Reserve University, Cleveland, OH, USA., Bourbeau DJ; Louis Stokes Cleveland VAMC, Cleveland, OH, USA.; Cleveland FES Center, Cleveland, OH, USA.; Department of Physical Medicine & Rehabilitation, MetroHealth Medical Center, Cleveland, OH, USA., Rajneesh CP; School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan., Peng CW; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.; School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Jun 24; Vol. 2019, pp. 1248342. Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
DOI: 10.1155/2019/1248342
Abstrakt: Background/purpose: Few studies have investigated the effects of changing the amplitude of dorsal genital nerve stimulation (GNS) on the inhibition of neurogenic detrusor overactivity in individuals with spinal cord injury (SCI). The present study determined the acute effects of changes in GNS amplitude on bladder capacity gain in individuals with SCI and neurogenic detrusor overactivity.
Methods: Cystometry was used to assess the effects of continuous GNS on bladder capacity during bladder filling. The cystometric trials were conducted in a randomized sequence of cystometric fills with continuous GNS at stimulation amplitudes ranging from 1 to 4 times of threshold (T) required to elicit the genitoanal reflex.
Results: The bladder capacity increased minimally and maximally by approximately 34% and 77%, respectively, of the baseline bladder capacity at 1.5 T and 3.2 T, respectively. Stimulation amplitude and bladder capacity were significantly correlated ( R = 0.55, P = 0.01).
Conclusion: This study demonstrates a linear correlation between the stimulation amplitude ranging from 1 to 4T and bladder capacity gain in individuals with SCI in acute GNS experiments. However, GNS amplitude out of the range of 1-4T might not be exactly a linear relationship due to subthreshold or saturation factors. Thus, further research is needed to examine this issue. Nevertheless, these results may be critical in laying the groundwork for understanding the effectiveness of acute GNS in the treatment of neurogenic detrusor overactivity.
Databáze: MEDLINE
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