New Antiproliferative Cembrane Diterpenes from the Red Sea Sarcophyton Species.

Autor: Hassan HM; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt., Rateb ME; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.; School of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK., Hassan MH; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt., Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt., Shabana S; Pharmacognosy Department, College of Pharmaceutical Sciences & Drug Manufacturing, Misr University for Science and Technology (MUST), Six October City 77, Egypt., Raslan M; Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt., Amin E; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62514, Egypt., Behery FA; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmaceutical Sciences, College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia., Ahmed OM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt., Bin Muhsinah A; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia., A M Gulder T; Chair of Technical Biochemistry, Department of Chemistry and Food Chemsitry, Technical University of Dresden, Bergestrabe 66, Dresden 01069, Germany. tobias.gulder@tu-dresden.de., Ramadan Abdelmohsen U; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. usama.ramadan@mu.edu.eg.
Jazyk: angličtina
Zdroj: Marine drugs [Mar Drugs] 2019 Jul 11; Vol. 17 (7). Date of Electronic Publication: 2019 Jul 11.
DOI: 10.3390/md17070411
Abstrakt: The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral Sarcophyton sp. This approach facilitated the isolation of five new cembrane-type diterpenoids ( 1 - 5 ), along with two known analogs ( 6 and 7 ), as well as the identification of 19 further, known compounds. The chemical structures of the new compounds were elucidated while using comprehensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) NMR and HRMS. All of the isolated cembranoids ( 1 - 7 ) showed moderate in vitro antiproliferative activity against a human breast cancer cell line (MCF-7), with IC 50 ranging from 22.39-27.12 µg/mL. This class of compounds could thus serve as scaffold for the future design of anticancer leads.
Databáze: MEDLINE
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