Cardiac autonomic neuropathy in patients with type 2 diabetes mellitus having peripheral neuropathy: A cross-sectional study.

Autor: Haq T; Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Electronic address: tahniyah81@bsmmu.edu.bd., Ahmed T; Department of Endocrinology, Bangladesh Institute of Research, Rehabilitation of Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh., Latif ZA; Department of Endocrinology, BIRDEM, Dhaka, Bangladesh., Sayeed MA; Department of Community Medicine, Ibrahim Medical College, Dhaka, Bangladesh., Ashrafuzzaman SM; Department of Endocrinology, BIRDEM, Dhaka, Bangladesh.
Jazyk: angličtina
Zdroj: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2019 Mar - Apr; Vol. 13 (2), pp. 1523-1528. Date of Electronic Publication: 2019 Mar 08.
DOI: 10.1016/j.dsx.2019.03.015
Abstrakt: Aims: The aim was to see the frequency of CAN in type 2 diabetes mellitus patients with peripheral neuropathy, and its association with peripheral nerve conduction abnormalities.
Methods: A cross-sectional study at BIRDEM was conducted in 62 patients with type 2 diabetes mellitus having electrophysiologically diagnosed peripheral neuropathy. CAN was detected by four clinical tests - heart rate response to deep breathing and valsalva maneuver, blood pressure response to standing and sustained handgrip.
Result: The study showed that all patients had CAN - 14.52% had early, 26.67% had definitive and 59.68% had severe CAN. Patients with severe CAN had significantly reduced nerve conduction velocity and amplitude of peripheral nerves (sural 4.36 ± 12.77 vs 9.65 ± 17.77 m/s, p = 0.009; 2.23 ± 1.89 vs 3.01 ± 2.76 mV, p = 0.001; peroneal 7 ± 4.23 vs 8.53 ± 5.99 mV, p = 0.047; tibial 0.008 ± 0.03 vs 0.026 ± 0.05 mV, p = 0.009) and higher serum triglyceride levels (221.17 ± 120.61 vs 197.76 ± 68.43 mg/dl, p = 0.033).
Conclusion: Diabetic patients with peripheral neuropathy have CAN, the severity of which increases with worsening neuropathy.
(Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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