Impact of Initial Antifungal Therapy on the Outcome of Patients With Candidemia and Septic Shock Admitted to Medical Wards: A Propensity Score-Adjusted Analysis.

Autor: Falcone M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Tiseo G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Gutiérrez-Gutiérrez B; Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/Departamento de Medicina, Universidad de Sevilla/Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain., Raponi G; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy., Carfagna P; San Giovanni Addolorata Hospital, Rome, Italy., Rosin C; University Hospital of Trieste, Trieste, Italy., Luzzati R; University Hospital of Trieste, Trieste, Italy., Delle Rose D; Clinical Infectious Diseases, Department of Systems Medicine, Tor Vergata University, Rome, Italy., Andreoni M; Clinical Infectious Diseases, Department of Systems Medicine, Tor Vergata University, Rome, Italy., Farcomeni A; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy., Venditti M; Department of Public Health and Infectious Diseases, 'Sapienza' University of Rome, Rome, Italy., Rodríguez-Baño J; Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/Departamento de Medicina, Universidad de Sevilla/Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain., Menichetti F; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2019 Jul 16; Vol. 6 (7), pp. ofz251. Date of Electronic Publication: 2019 Jul 16 (Print Publication: 2019).
DOI: 10.1093/ofid/ofz251
Abstrakt: Background: Echinocandins are recommended as firstline therapy in patients with candidemia. However, there is debate on their efficacy in survival outcomes. The aim of this study is to evaluate whether the choice of initial antifungal therapy improves mortality in patients with candidemia in relation to the presence of septic shock.
Methods: Patients with candidemia hospitalized in internal medicine wards of 5 tertiary care centers were included in the study (December 2012-December 2014). Patient characteristics, therapeutic interventions, and outcome were reviewed. Propensity score (PS) was used as a covariate of the multivariate analysis to perform a stratified analysis according to PS quartiles and to match patients receiving "echinocandins" or "azoles."
Results: Overall, 439 patients with candidemia were included in the study. A total of 172 (39.2%) patients had septic shock. Thirty-day mortality was significantly higher in patients with septic shock (45.3%) compared with those without septic shock (31.5%; P = .003). Among patients with septic shock, the use of echinocandins in the first 48 hours, compared with azoles, did not affect 30-day mortality in the PS-adjusted Cox regression analysis (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.37-1.59; P = .48), the PS-stratified analysis, or the logistic regression model in matched cohorts (adjusted HR, 0.92; 95% CI, 0.51-1.63; P = .77).
Conclusions: Echinocandin therapy seems not to improve the outcome of non-intensive care unit patients with septic shock due to candidemia. These findings support the urgent need of further studies in this patient population.
Databáze: MEDLINE
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