Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis in rats.

Autor:	Ramos MFP; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Oliveira OB; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., de Barros ADCMM; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Razvickas CV; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Pessoa EA; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., da Silva RF; Morphology and Genetics Division, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Pereira AMS; Biotechnology, Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil., Convento MB; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Borges FT; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.; Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil., Schor N; Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2019 Jul 09; Vol. 7, pp. e7219. Date of Electronic Publication: 2019 Jul 09 (Print Publication: 2019).
DOI:	10.7717/peerj.7219
Abstrakt:	Background: Hypotension, increased production of reactive oxygen species, and inflammation are all observed in experimental models of sepsis induced by lipopolysaccharide (LPS). Purpose: The aim of this study was to evaluate the effects of an ethanolic extract of Brazilian olive leaf (Ex), Brazilian olive oil (Olv), Ex + Olv (ExOlv), and palm oil (Pal) in comparison to the effects of omega-3 fish oil (Omg) in a rat model of sepsis-induced acute kidney injury. Materials: Wistar rats were divided into seven groups (seven per group), which were either untreated (control) or treated with LPS, LPS + Ex, LPS + ExOlv, LPS + Olv, LPS + Omg, or LPS + Pal. Results: Lower values of creatinine clearance and blood pressure were observed in the LPS-treated group, and these values were not affected by Ex, Olv, ExOlv, Pal, or Omg treatment. Mortality rates were significantly lower in rats exposed to LPS when they were also treated with Ex, ExOlv, Olv, Pal, or Omg. These treatments also decreased oxidative stress and inflammation (Tumor necrosis factor alpha, interleukin-1 beta) and increased interleukin-10 levels and cell proliferation, which were associated with decreased apoptosis in kidney tissue. Conclusion: Ex and Pal treatments were beneficial in septic rats, since they increased survival rate and did not aggravate inflammation. However, the most effective treatments for septic rats were Olv in comparison to Omg. These natural food substances could enable the development of effective therapeutic interventions to sepsis. Competing Interests: The authors declare that they have no competing interests.
Databáze:	MEDLINE
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