Long-Term Cortisol Exposure and Associations With Height and Comorbidities in Turner Syndrome.

Autor:	Savas M; Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Obesity Center Centrum Gezond Gewicht, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., Wester VL; Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Obesity Center Centrum Gezond Gewicht, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., Dykgraaf RHM; Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., van den Akker ELT; Obesity Center Centrum Gezond Gewicht, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Pediatric Endocrinology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., Roos-Hesselink JW; Cardiology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., Dessens AB; Child and Adolescent Psychiatry and Psychology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., de Graaff LCG; Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., de Rijke YB; Obesity Center Centrum Gezond Gewicht, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands., van Rossum EFC; Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Obesity Center Centrum Gezond Gewicht, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.; Turner Syndrome Expertise Center, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2019 Sep 01; Vol. 104 (9), pp. 3859-3867.
DOI:	10.1210/jc.2019-00148
Abstrakt:	Context: Turner syndrome (TS) usually manifests in traits as short stature and premature ovarian failure. Many patients also have an increased risk of cardiometabolic disorders and psychological distress, which are features that overlap with those of a prolonged state of hypercortisolism. Objective: To investigate whether TS is associated with increased long-term cortisol concentrations as measured in scalp hair and whether these are linked to cardiometabolic and psychological parameters. Design: Prospective observational case-control study. Setting: Academic outpatient TS expertise center. Participants: Fifty-five patients with TS (53% 45,X karyotype), and 110 age-matched female community control subjects from the general population-based Lifelines cohort study. Main Outcome Measures: Hair cortisol concentrations (HCC), anthropometrics, biochemical parameters, and psychological questionnaires for perceived stress (Perceived Stress Scale-14), fatigue (Checklist Individual Strength-20), and health-related quality of life (RAND-36). Results: Compared with control subjects, patients with TS had higher HCC [geometric mean, 3.51 pg/mg (95% CI, 2.64 to 4.65) vs 2.39 pg/mg (2.13 to 2.68); P = 0.003] and a worse cardiometabolic profile in terms of fasting glucose, and triglycerides. HCC was only associated with total cholesterol levels (standardized β = 0.294; P = 0.047) and was not associated with the psychological outcomes. A higher HCC was inversely associated with height only in patients with TS (standardized β = -0.307; P = 0.023). Conclusion: Patients with TS are chronically exposed to higher cortisol levels, which is associated with short stature and increased total cholesterol levels, and potentially contributes to the known elevated cardiovascular disease risk. (Copyright © 2019 Endocrine Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu