An Introduction to Pathology in Biomedical Research: A Mission-Critical Specialty for Reproducibility and Rigor in Translational Research.

Autor:	Brayton CF; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland., Boyd KL; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee., Everitt JL; Department of Pathology, Duke University School of Medicine, Durham, North Carolina., Meyerholz DK; Department of Pathology, University of Iowa, Iowa City, Iowa., Treuting PM; Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington., Bolon B; GEMpath Inc. Longmont, Colorado.
Jazyk:	angličtina
Zdroj:	ILAR journal [ILAR J] 2018 Dec 01; Vol. 59 (1), pp. 1-3.
DOI:	10.1093/ilar/ilz008
Abstrakt:	This issue of ILAR Journal focusses on pathology and pathologists in biomedical research, more specifically in preclinical translational research involving (nonhuman) animals, emphasizing academic settings. Considerations in study design and planning to maximize benefit from pathologists and pathology resources are reviewed. Adjunctive technologies including molecular techniques, digital pathology, and imaging are highlighted. Additional considerations regarding safety and regulatory concerns, and veterinary clinical trials are reviewed as well. Pathology has been fundamental to understanding clinical disease, remains fundamental to diagnosing disease, and is required in drug and device development. Broader integration of pathology expertise and well-designed pathology investigations have much to offer research rigor and reproducibility, and successful translation from biomedical research. (© The Author(s) 2019. Published by Oxford University Press on behalf of the National Academy of Sciences. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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