Phialomyces macrosporus: Chemical Constituents, Antimicrobial Activity and Complete NMR Assignments for the 7,7'-Biphyscion.

Autor: da Silva Brandão M; Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Rua Barão de Jeremoabo, 147 - Ondina, Salvador -, BA 40170-115, Brazil., Silva Abreu L; Laboratório Multiusuário de Caracterização e Análise, Centro de Ciências da Saúde, Universidade Federal da Paraíba, Cidade Universitária, SN - Castelo Branco, João Pessoa -, PB 58051-900, Brazil., Geris R; Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Rua Barão de Jeremoabo, 147 - Ondina, Salvador -, BA 40170-115, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2019 Sep; Vol. 16 (9), pp. e1900353. Date of Electronic Publication: 2019 Aug 20.
DOI: 10.1002/cbdv.201900353
Abstrakt: Five known secondary metabolites, chrysophanol (1), 7,7'-biphyscion (2), secalonic acid D (3), mannitol (4) and trehalose (5) were isolated for the first time from the extracts of the fungus Phialomyces macrosporus. Their structures were elucidated by NMR methods (1D and 2D NMR analysis), optical activity and ESI-MS. Complete 1 H and 13 C assignments were performed for compound 2. The antimicrobial activity was evaluated by serial microdilution assay for compounds 2 and 3 and results showed that compound 3 exhibited a significant growth inhibition at concentrations of 15.6 mg/ml (S. aureus and S. choleraesius) and 0.97 mg/mL (B. subtilis), comparable to the positive control.
(© 2019 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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