Maternal and fetal thiol/disulfide homeostasis in fetal growth restriction.
| Autor: | Eroglu H; Maternal Fetal Medicine, Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey., Turgal M; Obstetrics and Gynecology, Koc University Hospital, Topkapi, Turkey., Senat A; Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey., Karakoc G; Maternal Fetal Medicine, Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey., Neselioglu S; Biochemistry, Yildirim Beyazit Universitesi Tip Fakultesi, Ankara, Turkey., Yucel A; Maternal Fetal Medicine, Etlik Zubeyde Hanim Kadin Hastaliklari Egitim ve Arastirma Hastanesi, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2021 May; Vol. 34 (10), pp. 1658-1665. Date of Electronic Publication: 2019 Aug 05. |
| DOI: | 10.1080/14767058.2019.1646239 |
| Abstrakt: | Purpose: To evaluate thiol/disulfide homeostasis in both maternal and fetal compartment in the presence of fetal growth restriction (FGR). Materials and Methods: A prospective case-control study was carried out in women with FGR ( n : 40) or normally growing fetus ( n : 40). FGR was defined as estimated fetal weight below the 10th percentile for the gestational age. Maternal serum and fetal cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance. Results: Native thiol, total thiol and disulfide amounts were decreased in the maternal serum and fetal cord blood of babies born to women with FGR ( p < .05). The most sensitive marker was maternal native thiol (82.5, 95% confidence interval, 67.22-92.66%), while the maternal total thiol had highest specificity value (77.5, 95% confidence interval, 61.55-89.16%). Conclusions: Maternal and fetal serum thiol/disulfide profiles may use prediction of FGR severity and its neonatal outcome. |
| Databáze: | MEDLINE |
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