Ambient fine particulate matter and ozone higher than certain thresholds associated with myopia in the elderly aged 50 years and above.

Autor: Ruan Z; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Qian ZM; College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63104, USA., Guo Y; Shanghai Municipal Centre for Disease Control and Prevention, Shanghai 200336, China., Zhou J; Guangzhou Woman and Children's Medical Center, Guangzhou, China., Yang Y; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Acharya BK; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Guo S; South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, China., Zheng Y; Shanghai Municipal Centre for Disease Control and Prevention, Shanghai 200336, China., Cummings-Vaughn LA; Division of Geriatrics and Nutritional Science, School of Medicine, Washington University-St. Louis, St. Louis, MO 63110, USA., Rigdon SE; College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63104, USA., Vaughn MG; College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63104, USA., Chen X; School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China., Wu F; Shanghai Municipal Centre for Disease Control and Prevention, Shanghai 200336, China. Electronic address: wufan@scdc.sh.cn., Lin H; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: linhualiang@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2019 Oct; Vol. 177, pp. 108581. Date of Electronic Publication: 2019 Jul 09.
DOI: 10.1016/j.envres.2019.108581
Abstrakt: Although myopia has been largely ignored among the elderly population, there is an increased risk of myopia with advancing age. Ambient air pollution is one potential contributor to vision impairments, but few epidemiological studies have demonstrated such an association. This cross-sectional survey collected the information of 33,626 subjects aged ≥50 years in six developing countries during 2007-2010. Myopia was identified based on questions related to symptoms of myopia. The annual concentrations of fine particulate matter (PM 2.5 ) and ozone (O 3 ) were estimated with the satellite data and chemical transport model. We examined the associations between the two pollutants and myopia using mixed-effect Poisson regression models with robust variance estimation (sandwich estimation). We observed J-shaped associations between the two pollutants and myopia, and identified 12 and 54 μg/m 3 as the threshold concentrations. The adjusted prevalence ratio was 1.12 (95% CI: 1.05, 1.21) and 1.26 (95% CI: 1.14, 1.38) for each standard deviation (SD) increase in PM 2.5 and O 3 concentrations above their threshold, respectively. In addition, the interaction analysis suggested a synergistic interaction of these two pollutants on myopia in the additive model, with a synergistic index of 1.81 (Bootstrapping 95% CI: 0.92, 4.94). Our results indicate that long-term exposures to PM 2.5 and O 3 might be important environmental risk factors of myopia in the elderly, and suggest that more efforts should be taken to reduce airborne PM 2.5 and O 3 levels to protect vision health.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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