Cognitive functioning as a predictor of employment status in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.

Autor: van Gorp DAM; National Multiple Sclerosis Foundation, Mathenesserlaan 378, 3023 HB, Rotterdam, The Netherlands. dennis.vangorp@phd.uvh.nl.; Department of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, PO Box 9555, 2300 RB, Leiden, The Netherlands. dennis.vangorp@phd.uvh.nl.; Department of Neurology, Elisabeth-TweeSteden Hospital, PO Box 90151, 5000 LC, Tilburg, The Netherlands. dennis.vangorp@phd.uvh.nl.; Department of Care Ethics, University of Humanistic Studies, PO Box 797, 3500 AT, Utrecht, Utrecht, The Netherlands. dennis.vangorp@phd.uvh.nl., van der Hiele K; National Multiple Sclerosis Foundation, Mathenesserlaan 378, 3023 HB, Rotterdam, The Netherlands.; Department of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, PO Box 9555, 2300 RB, Leiden, The Netherlands.; Department of Neurology, Elisabeth-TweeSteden Hospital, PO Box 90151, 5000 LC, Tilburg, The Netherlands., Heerings MAP; National Multiple Sclerosis Foundation, Mathenesserlaan 378, 3023 HB, Rotterdam, The Netherlands., Jongen PJ; Department of Health Sciences, Community and Occupational Medicine, University Medical Centre Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.; MS4 Research Institute, Ubbergseweg 34, 9522 KJ, Nijmegen,, The Netherlands., van der Klink JJL; Department of Social and Behavioral Sciences, Tranzo Scientific Centre for Care and Welfare, Tilburg University, PO Box 90153, 5000 LE, Tilburg, The Netherlands., Reneman MF; Department of Rehabilitation Medicine, Center for Rehabilitation, University of Groningen, University Medical Center Groningen, PO Box 30.002, 9750 RA, Haren, The Netherlands., Arnoldus EPJ; Department of Neurology, Elisabeth-TweeSteden Hospital, PO Box 90151, 5000 LC, Tilburg, The Netherlands., Beenakker EAC; Department of Neurology, Medical Centre Leeuwarden, PO Box 888, 8901 BR, Leeuwarden, The Netherlands., van Eijk JJJ; Department of Neurology, Jeroen Bosch Hospital, PO Box 90153, 2000 ME, 's-Hertogenbosch, The Netherlands., Frequin STFM; Department of Neurology, St. Antonius Hospital, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands., de Gans K; Department of Neurology, Groene Hart Hospital, PO Box 1098, 2800 BB, Gouda, The Netherlands., Hoitsma E; Department of Neurology, Alrijne Hospital Leiden, PO Box 9650, 2300 RD, Leiden, The Netherlands., Mostert JP; Department of Neurology, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands., Verhagen WIM; Department of Neurology, Canisius-Wilhelmina Hospital, PO Box 9015, 6500 GS, Nijmegen, The Netherlands., Zemel D; Department of Neurology, Albert Schweitzer Hospital, PO Box 444, 330 AK, Dordrecht, The Netherlands., Visser LH; Department of Neurology, Elisabeth-TweeSteden Hospital, PO Box 90151, 5000 LC, Tilburg, The Netherlands.; Department of Care Ethics, University of Humanistic Studies, PO Box 797, 3500 AT, Utrecht, Utrecht, The Netherlands., Middelkoop HAM; Department of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, PO Box 9555, 2300 RB, Leiden, The Netherlands.; Department of Neurology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2019 Dec; Vol. 40 (12), pp. 2555-2564. Date of Electronic Publication: 2019 Jul 19.
DOI: 10.1007/s10072-019-03999-w
Abstrakt: Background: Cognitive functioning has been linked to employment outcomes in multiple sclerosis (MS) in cross-sectional studies. Longitudinal studies are however lacking and previous studies did not extensively examine executive functioning.
Objectives: We examined whether baseline cognitive functioning predicts a change in employment status after 2 years, while taking into account mood, fatigue and disability level.
Methods: A total of 124 patients with relapsing-remitting MS (pwMS) and 60 healthy controls were included. They underwent neurological and neuropsychological examinations and completed online questionnaires. PwMS were divided into a stable and deteriorated employment status group (SES and DES), based on employment status 2 years after baseline. We first examined baseline differences between the SES and DES groups in cognitive functioning, mood, fatigue and disability level. A logistic regression analysis was performed, with change in employment status (SES/DES) as dependent variable.
Results: The DES group included 22% pwMS. Group differences were found in complex attention, executive functioning, self-reported cognitive functioning, fatigue and physical disability. More physical disability (OR = 1.90, p = 0.01) and lower executive functioning (OR = 0.30, p = 0.03) were retained as independent predictors of DES (R 2  = 0.22, p ≤ 0.001).
Conclusions: Baseline physical disability and executive functioning, but none of the other variables, moderately predicted a deterioration in employment status 2 years later.
Trial Registration: This observational study is registered under NL43098.008.12: 'Voorspellers van arbeidsparticipatie bij mensen met relapsing-remitting Multiple Sclerose'. This study is registered at the Dutch CCMO register (https://www.toetsingonline.nl).
Databáze: MEDLINE
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