CYTOGENETIC BIODOSIMETRY OF ACCIDENTAL EXPOSURES IN THE LONG TERMS AFTER IRRADIATION.

Autor:	Nugis VY; Center of Biomedical Technology of State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia., Kozlova MG; Center of Biomedical Technology of State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia., Nadejina NM; Center of Biomedical Technology of State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia., Galstyan IA; Center of Biomedical Technology of State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia., Nikitina VA; Center of Biomedical Technology of State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia., Khvostunov IK; Laboratory of Radiation Cytogenetics of A. Tsyb Medical Radiological Research Center-branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia., Golub EV; Laboratory of Radiation Cytogenetics of A. Tsyb Medical Radiological Research Center-branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2019 Dec 31; Vol. 186 (1), pp. 31-36.
DOI:	10.1093/rpd/ncz040
Abstrakt:	The group of radiation victims who had received radiation injures similar to those of Chernobyl accident victims was evaluated in terms of retrospective cytogenetic biodosimetry in the long term period of from 17 y up to 50 y after irradiation. Based on the existing results of the long-term cytogenetic examination of the victims injured after the Chernobyl accident, an original method was developed. This method of retrospective dose recovery was based on the use of a special computer program, the time elapsed after irradiation and the frequency of atypical chromosomes. Both patient groups were examined using conventional cytogenetic analysis. The new method of a retrospective biodosimetry was tested on the non-Chernobyl group. As a result the multiple regression equations which included frequency atypical chromosomes produced better results because the majority of the estimates of the retrospective doses fell into the 95%-prediction intervals for the reference group of the Chernobyl victims. (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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