Human Papillomavirus and Coronary Artery Disease in Climacteric Women: Is There an Association?

Autor: Brito LMO; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Brito HO; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Corrêa RDGCF; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., de Oliveira Neto CP; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Costa JPL; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Monteiro SCM; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Vidal FCB; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Nascimento MDDSB; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., de Figueiredo Neto JA; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., Gil da Costa RM; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil.; Molecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology, Porto, Portugal., Galvão-Moreira LV; Tumor and DNA Biobank of Maranhão, Federal University of Maranhão, São Luís, Brazil., da Silva IDCG; Federal University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: TheScientificWorldJournal [ScientificWorldJournal] 2019 Jun 20; Vol. 2019, pp. 1872536. Date of Electronic Publication: 2019 Jun 20 (Print Publication: 2019).
DOI: 10.1155/2019/1872536
Abstrakt: Background: Cardiovascular diseases are leading causes of death worldwide. Recent studies suggest that infection by some viruses, including the human papillomavirus (HPV), may increase the risk of developing atheromatous lesions on coronary arteries. However, there is a lack of data regarding the possible association between HPV infection and coronary artery disease (CAD) in women.
Objective: To investigate whether HPV infection is associated with the occurrence of CAD among climacteric women.
Methods: The presence of CAD and cervical HPV DNA was investigated in 52 climacteric women. Social and demographic variables and metabolic profiles were also investigated.
Results: Among 27 women with CAD, 16 were positive for HPV, whereas 11 were negative. The presence of cervical HPV was strongly associated with CAD, after adjusting for demographic variables, health and sexual behaviors, comorbidities, and known cardiovascular risk factors. HPV-positive women showed a greater likelihood of having CAD (odds ratio [OR] = 3.74; 95% confidence interval [CI]: 1.16 to 11.96) as compared with HPV-negative women, particularly those infected with high-risk HPV types (OR = 4.90; 95% CI: 1.26 to 19.08).
Conclusion: These results support the hypothesis that HPV infection might be associated with CAD among climacteric women, though further studies are needed to investigate the mechanisms involved.
Databáze: MEDLINE
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