Revisiting the hallmarks of cancer: The role of hyaluronan.

Autor: Caon I; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Bartolini B; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Parnigoni A; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Caravà E; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Moretto P; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Viola M; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Karousou E; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy., Vigetti D; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy. Electronic address: Davide.vigetti@uninsubria.it., Passi A; Department of Medicine and Surgery, University of Insubria - via J.H. Dunant 5, 21100, Varese, Italy. Electronic address: alberto.passi@uninsubria.it.
Jazyk: angličtina
Zdroj: Seminars in cancer biology [Semin Cancer Biol] 2020 May; Vol. 62, pp. 9-19. Date of Electronic Publication: 2019 Jul 15.
DOI: 10.1016/j.semcancer.2019.07.007
Abstrakt: Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans (PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and organs. The main role of ECM is not only to provide an essential mechanical scaffold for the cells but also to mediate crucial biochemical cues that are required for tissue homeostasis. Dysregulations in ECM deposition alter cell microenvironment, triggering the onset or the rapid progression of several diseases, including cancer. Hyaluronan (HA) is a ubiquitous component of ECM considered as one of the main players of cancer initiation and progression. This review discusses how HA participate in and regulate several aspects of tumorigenesis, with particular attention to the hallmarks of cancer proposed by Hanahan and Weinberg such as sustaining of the proliferative signaling, evasion of apoptosis, angiogenesis, activation of invasion and metastases, reprogramming of energy metabolism and evasion of immune response.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest with the content of the present review.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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