[Augmentation with carnicetine for late depression].

Autor:	Safarova TP; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia., Gavrilova SI; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia., Yakovleva OB; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia., Sheshenin VS; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia., Kornilov VV; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia., Shipilova ES; Mental Health Research Center, Ministry of Scienes and Higher Education Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2019; Vol. 119 (5), pp. 65-75.
DOI:	10.17116/jnevro201911905165
Abstrakt:	Aim: Comparative evaluation of the efficacy and safety of antidepressant monotherapy and complex antidepressant therapy in combination with carnicetine in the treatment of depression in elderly patients in a psychiatric hospital. Material and Methods: Two groups of hospitalized patients, aged from 60 to 79 years, with mild or moderate depression (according to ICD-10), comparable in basic demographic and clinical characteristics, received mono- or complex (in combination with carnicetine) antidepressant therapy for 8 weeks. Treatment efficacy was assessed with HAM-D, HARS, CGI-S and CGI-I; the level of cognitive activity was assessed with MMSE, the 10-word memory test and clock drawing test. Results: It has been established that the use of complex antidepressants therapy with the inclusion of carnicetine allows to achieve a more rapid and pronounced therapeutic response compared to antidepressant monotherapy. This is confirmed by the earlier (by the 4th week) and significant reduction of depressive and anxiety symptoms (p<0.01), a greater number of responders and better quality of depressive outcomes to the end of treatment and a more rapid improvement in cognitive functioning. Conclusion: The results allow us to recommend the inclusion of carnicetine for the augmentation of antidepressant therapy in elderly patients of the psychiatric hospital to achieve a more rapid and complete therapeutic response and reduce the duration of hospitalization.
Databáze:	MEDLINE
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