Mechanistic insights of Cu(ii)-mediated ortho-C-H amination of arenes by capturing fleeting intermediates and theoretical calculations.

Autor: Kumar M; Department of Chemistry, University of Delhi, Delhi 110007, India. averma@acbr.du.ac.in., Verma S; Department of Chemistry, University of Delhi, Delhi 110007, India. averma@acbr.du.ac.in., Kumar A; Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India. raghurama@iisertirupati.ac.in shibdas@iisertirupati.ac.in., Mishra PK; Department of Chemistry, University of Delhi, Delhi 110007, India. averma@acbr.du.ac.in., Ramabhadran RO; Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India. raghurama@iisertirupati.ac.in shibdas@iisertirupati.ac.in., Banerjee S; Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India. raghurama@iisertirupati.ac.in shibdas@iisertirupati.ac.in., Verma AK; Department of Chemistry, University of Delhi, Delhi 110007, India. averma@acbr.du.ac.in.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Aug 14; Vol. 55 (63), pp. 9359-9362. Date of Electronic Publication: 2019 Jul 18.
DOI: 10.1039/c9cc04317a
Abstrakt: The capture of reactive intermediates empowers chemists to conjecture the detail of a chemical transformation. Here we explore the mechanism of a C-H amination by intercepting short-lived intermediates in real time using online mass spectrometry. Computational study unravels the favorable pathway of the proposed dual mechanism of the reaction.
Databáze: MEDLINE
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