[Research advances in the role of mTOR signaling pathway in autism spectrum disorder].

Autor: Sheng GX; Department of Neurology, Children's Hospital of Zhejiang University, Hangzhou 310000, China. jiangkw_zju@zju.edu.cn., Jiang KW
Jazyk: čínština
Zdroj: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2019 Jul; Vol. 21 (7), pp. 718-723.
Abstrakt: Mammalian target of rapamycin (mTOR) is an intracellular signaling pathway molecule which regulates various fundamental physiological processes. The mTOR signaling pathway plays an important role in synaptic plasticity, information transmission and processing, and neuroregulation. Dysregulation of the mTOR signaling pathway is generally considered to be related to the pathogenesis of autism spectrum disorder (ASD); meanwhile, the mTOR inhibitor can ameliorate the symptoms of ASD. The role of mTOR in the pathogenesis of ASD is summarized in this article to provide a theoretical basis for targeted therapy of ASD.
Databáze: MEDLINE