Relationship between nucleotide-binding oligomerization domain-containing protein 2 variants and severity of acute pancreatitis.

Autor:	Harputluoglu MMM; Inonu University Medical Faculty, Department of Gastroenterology, Malatya, Turkey., Ozbek M; Inonu University Medical Faculty, Department of Internal Medicine, Malatya, Turkey., Demirel U; Firat University Medical Faculty, Department of Gastroenterology, Elazig, Turkey., Otlu B; Inonu University Medical Faculty, Department of Microbiology, Malatya, Turkey., Yener O; Inonu University Medical Faculty, Department of Microbiology, Malatya, Turkey., Gursoy NC; Inonu University Medical Faculty, Department of Microbiology, Malatya, Turkey., Tikici D; Ankara Numune Training and Research Hospital, Department of General Surgery, Ankara., Erdogan MA; Inonu University Medical Faculty, Department of Gastroenterology, Malatya, Turkey., Caliskan AR; Inonu University Medical Faculty, Department of Gastroenterology, Malatya, Turkey., Dertli R; Necmettin Erbakan University, Meram Medical Faculty, Department of Gastroenterology, Konya, Turkey.
Jazyk:	angličtina
Zdroj:	Acta gastro-enterologica Belgica [Acta Gastroenterol Belg] 2019 Apr-Jun; Vol. 82 (2), pp. 285-290.
Abstrakt:	Background and Aim: Intestinal barrier dysfunction has been implicated in the development of infectious complications of acute pancreatitis. Nucleotide-Binding Oligomerization DomainContaining Protein 2 (NOD2) plays an important role in the proper functioning of intestinal defense mechanisms. Here, we investigated the frequency of NOD2 variants in patients with mild and severe acute pancreatitis. Materials and Methods: Groups 1, 2 and 3 comprised healthy participants and patients with mild and severe pancreatitis, respectively. Four NOD2 variants and serum interleukin-6 (IL-6), Tumor Necrosis Factor-a (TNF-a) and lipopolysaccharide-binding protein (LBP) levels were analyzed. Results: Three patients (3/32, 9.4%) in the severe pancreatitis group were positive for the p.R702W variant. This variant was negative in other groups. One, three and three patients in the healthy (1/27, 3.7%), mild (3/36, 8.3%) and severe pancreatitis (3/32, 9.4%) groups tested positive for the 1007fs variant, respectively. No significant differences in the frequencies of NOD2 variants were evident among the groups. Serum IL-6, TNF-a and LBP levels were markedly higher in the severe pancreatitis than the healthy and mild pancreatitis groups (all p<0.001). We observed no significant correlation between cytokine levels and NOD2 variants. Conclusion: Our results support an association between the presence of the p.R702W variant and severe pancreatitis. Competing Interests: The authors declare that they have no conflict of interest (© Acta Gastro-Enterologica Belgica.)
Databáze:	MEDLINE
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