Dyskeratosis Congenita and Corneal Refractive Surgery.

Autor: Heiland MB; The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA., Moshirfar M; John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. cornea2020@me.com.; Utah Lions Eye Bank, Murray, UT, USA. cornea2020@me.com.; Hoopes Durrie Rivera Research Center, Hoopes Vision, Draper, UT, USA. cornea2020@me.com., Rosen DB; The University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA., Ronquillo YC; Hoopes Durrie Rivera Research Center, Hoopes Vision, Draper, UT, USA., Hoopes PC; Hoopes Durrie Rivera Research Center, Hoopes Vision, Draper, UT, USA.
Jazyk: angličtina
Zdroj: Ophthalmology and therapy [Ophthalmol Ther] 2019 Sep; Vol. 8 (3), pp. 361-365. Date of Electronic Publication: 2019 Jul 16.
DOI: 10.1007/s40123-019-0200-z
Abstrakt: Dyskeratosis congenita is a syndrome of bone marrow failure secondary to unstable telomeres. It is characterized by a range of mucocutaneous diseases. Due to premature telomere shortening, these patients have limbal stem cell deficiency leading to poor regeneration and maintenance of the cornea. Many of these patients will require hematopoietic stem cell transplant in their lifetime, which poses a significant risk for acute and chronic graft-versus-host disease with and without ocular manifestations. We advise against elective corneal refractive surgery in patients with dyskeratosis congenita due to the compounded and long-term risks of delayed healing secondary to limbal stem cell deficiency and ocular complications of graft-versus-host disease post-allogeneic hematopoietic stem cell transplant.
Databáze: MEDLINE
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