Recommendations for Anti-inflammatory Treatments in Alzheimer's Disease: A Comprehensive Review of the Literature.
| Autor: | Ali MM; Internal Medicine, Mayo Hospital, King Edward Medical University, Lahore, PAK., Ghouri RG; Internal Medicine, Mayo Hospital, King Edward Medical University, Lahore, PAK., Ans AH; Cardiology, University of Pennsylvania, Philadelphia, USA., Akbar A; Internal Medicine, Rawalpindi Medical College, Rawalpindi, PAK., Toheed A; Internal Medicine, Mayo Hospital, King Edward Medical University, Lahore, PAK. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2019 May 08; Vol. 11 (5), pp. e4620. Date of Electronic Publication: 2019 May 08. |
| DOI: | 10.7759/cureus.4620 |
| Abstrakt: | Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, affecting individuals older than 60 years. It is a complex degenerative brain disease characterized by progressive cognitive impairment. AD constitutes a major global health concern. A central role for inflammation has been implicated in the pathogenesis of AD. Despite the understanding of multiple molecular pathways in the pathophysiology of AD, novel treatment agents with a possible role in modifying the disease activity are still lacking. Our article provides a comprehensive review of various observational studies and randomized trials encompassing the use of anti-inflammatory agents in the management of AD patients and utilizes the conclusions derived therefrom to give recommendations in this regard. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
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