Beta-sarcoglycan-deficient muscular dystrophy presenting as chronic bronchopneumonia in a young cat.

Autor:	Bouillon J; Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Taylor SM; Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Vargo C; Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Lange M; Martensville Veterinary Hospital, Martensville, Saskatchewan, Canada., Zwicker LA; Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Sukut SL; Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Guo LT; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA., Shelton GD; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Jazyk:	angličtina
Zdroj:	JFMS open reports [JFMS Open Rep] 2019 Jul 01; Vol. 5 (2), pp. 2055116919856457. Date of Electronic Publication: 2019 Jul 01 (Print Publication: 2019).
DOI:	10.1177/2055116919856457
Abstrakt:	Case Summary: A 5-month-old cat was evaluated for a 3 week history of cough, nasal discharge, decreased appetite and weight loss. Musculoskeletal examination was normal and serum creatine kinase (CK) activity was within the reference interval. The cat was treated during the next 10 months for chronic, persistent pneumonia. Weakness then became apparent, the cat developed dysphagia and was euthanized. Post-mortem evaluation revealed chronic aspiration pneumonia and muscular dystrophy associated with beta (β)-sarcoglycan deficiency. Relevance and Novel Information: This is the first report of a cat with muscular dystrophy presenting for chronic pneumonia without obvious megaesophagus, dysphagia or prominent neuromuscular signs until late in the course of the disease. The absence of gait abnormalities, marked muscle atrophy or hypertrophy and normal serum CK activity delayed the diagnosis in this cat with β-sarcoglycan deficiency. Competing Interests: Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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