Cutting Edge: Bacillus Calmette-Guérin-Induced T Cells Shape Mycobacterium tuberculosis Infection before Reducing the Bacterial Burden.
Autor: | Delahaye JL; Seattle Children's Research Institute, Seattle, WA 98109.; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109; and., Gern BH; Seattle Children's Research Institute, Seattle, WA 98109., Cohen SB; Seattle Children's Research Institute, Seattle, WA 98109., Plumlee CR; Seattle Children's Research Institute, Seattle, WA 98109., Shafiani S; Seattle Children's Research Institute, Seattle, WA 98109., Gerner MY; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109; and., Urdahl KB; Seattle Children's Research Institute, Seattle, WA 98109; kevin.urdahl@seattlechildrens.org.; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109; and.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98109. |
---|---|
Jazyk: | angličtina |
Zdroj: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Aug 15; Vol. 203 (4), pp. 807-812. Date of Electronic Publication: 2019 Jul 15. |
DOI: | 10.4049/jimmunol.1900108 |
Abstrakt: | Growing evidence suggests the outcome of Mycobacterium tuberculosis infection is established rapidly after exposure, but how the current tuberculosis vaccine, bacillus Calmette-Guérin (BCG), impacts early immunity is poorly understood. In this study, we found that murine BCG immunization promotes a dramatic shift in infected cell types. Although alveolar macrophages are the major infected cell for the first 2 weeks in unimmunized animals, BCG promotes the accelerated recruitment and infection of lung-infiltrating phagocytes. Interestingly, this shift is dependent on CD4 T cells, yet does not require intrinsic recognition of Ag presented by infected alveolar macrophages. M. tuberculosis -specific T cells are first activated in lung regions devoid of infected cells, and these events precede vaccine-induced reduction of the bacterial burden, which occurs only after the colocalization of T cells and infected cells. Understanding how BCG alters early immune responses to M. tuberculosis provides new avenues to improve upon the immunity it confers. (Copyright © 2019 by The American Association of Immunologists, Inc.) |
Databáze: | MEDLINE |
Externí odkaz: |