Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine.
Autor: | Chawla B; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Mahajan B; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Oakley M; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Majam VF; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Belmonte A; Naval Medical Research Center, Silver Spring, Maryland, USA., Sedegah M; Naval Medical Research Center, Silver Spring, Maryland, USA., Shimp RL Jr; Laboratory of Malaria Immunology and Vaccinology, NIAID, NIH, Rockville, Maryland, USA., Kaslow DC; PATH Essential Medicines, Seattle, Washington, USA., Kumar S; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Sanjai.Kumar@fda.hhs.gov. |
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Jazyk: | angličtina |
Zdroj: | Infection and immunity [Infect Immun] 2019 Sep 19; Vol. 87 (10). Date of Electronic Publication: 2019 Sep 19 (Print Publication: 2019). |
DOI: | 10.1128/IAI.00236-19 |
Abstrakt: | The development of effective malaria vaccines is hampered by incomplete understanding of the immunological correlates of protective immunity. Recently, the moderate clinical efficacy of the Plasmodium falciparum circumsporozoite protein (CSP)-based RTS,S/AS01 (Copyright © 2019 American Society for Microbiology.) |
Databáze: | MEDLINE |
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