The effect of a novel Bayesian penalised likelihood PET reconstruction algorithm on the assessment of malignancy risk in solitary pulmonary nodules according to the British Thoracic Society guidelines.

Autor: Murphy DJ; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. Electronic address: david.murphy@st-vincents.ie., Royle L; Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Chalampalakis Z; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK., Alves L; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK., Martins N; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK., Bassett P; Statsconsultancy Ltd., London, UK., Breen R; Department of Respiratory Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Nair A; Department of Radiology, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Bille A; Department of Cardiothoracic Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Chicklore S; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Cook GJ; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Subesinghe M; King's College London & Guy's and St. Thomas' PET Centre, St. Thomas' Hospital, London, UK; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2019 Aug; Vol. 117, pp. 149-155. Date of Electronic Publication: 2019 Jun 10.
DOI: 10.1016/j.ejrad.2019.06.005
Abstrakt: Purpose: British Thoracic Society (BTS) guidelines advocate using FDG PET-CT with the Herder model to estimate malignancy risk in solitary pulmonary nodules (SPNs). Qualitative and semi-quantitative assessment of SPN uptake is based upon analysis of Ordered Subset Expected Maximisation (OSEM) PET images. Our aim was to assess the effect of a Bayesian Penalised Likelihood (BPL) PET reconstruction on the assessment of SPN FDG uptake and estimation of malignancy risk (Herder score).
Methods: Subjects with SPNs who underwent FDG PET-CT between 2014-2017, with histological confirmation of malignancy or histological/imaging follow-up confirmation of benignity were included. Two blinded readers independently classified SPN uptake on both OSEM and BPL (BTS score; 1 = none; 2 = ≤ mediastinal blood pool (MBP); 3 = >MBP but ≤ 2x liver; 4 = >2x liver), with resultant calculation of the Herder score (%) for both reconstructions.
Results: 97 subjects with 75 (77%) malignant SPNs were included. BPL increased the BTS score in 25 (26%) SPNs; 9 SPNs (7 malignant) increased from BTS score 2 to 3, 16 (13 malignant) from BTS score 3 to 4, with a mean Herder score increase of 18 ± 22%. The mean Herder score for all SPNs with BPL was higher than OSEM (73 ± 29 vs 68 ± 32%, p = 0.001). There was no difference in Herder model diagnostic performance between BPL and OSEM, with similar areas under the curve (0.84 vs 0.83, p = 0.39).
Conclusion: BPL increases the Herder score in 26% of SPNs compared to OSEM but does not alter the diagnostic performance of the Herder model.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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