Circulating mRNA signature as a marker for high-risk prostate cancer.

Autor:	Souza MF; Department of General Biology, State University of Londrina, Londrina, Paraná, Brazil., Kuasne H; International Research Center-CIPE-A.C.Camargo Cancer Center, São Paulo, SP, Brazil., Barros-Filho MC; International Research Center-CIPE-A.C.Camargo Cancer Center, São Paulo, SP, Brazil., Cilião HL; Department of General Biology, State University of Londrina, Londrina, Paraná, Brazil., Marchi FA; International Research Center-CIPE-A.C.Camargo Cancer Center, São Paulo, SP, Brazil., Fuganti PE; Londrina Cancer Hospital, Londrina, Paraná, Brazil., Rogatto SR; Department of Clinical Genetics, University Hospital, Institute of Regional Health Research, University of Southern Denmark, Vejle, Denmark., Cólus IMS; Department of General Biology, State University of Londrina, Londrina, Paraná, Brazil.
Jazyk:	angličtina
Zdroj:	Carcinogenesis [Carcinogenesis] 2020 Apr 22; Vol. 41 (2), pp. 139-145.
DOI:	10.1093/carcin/bgz129
Abstrakt:	Prostate cancer (PCa) is the second most common cancer in men. The indolent course of the disease makes the treatment choice a challenge for physicians and patients. In this study, a minimally invasive method was used to evaluate the potential of molecular markers in identifying patients with aggressive disease. Cell-free plasma samples from 60 PCa patients collected before radical prostatectomy were used to evaluate the levels of expression of eight genes (AMACR, BCL2, NKX3-1, GOLM1, OR51E2, PCA3, SIM2 and TRPM8) by quantitative real-time PCR. Overexpression of AMACR, GOLM1, TRPM8 and NKX3-1 genes was significantly associated with aggressive disease characteristics, including extracapsular extension, tumor stage and vesicular seminal invasion. A trio of genes (GOLM1, NKX3-1 and TRPM8) was able to identify high-risk PCa cases (85% of sensitivity and 58% of specificity), yielding a better overall performance compared with the biopsy Gleason score and prostate-specific antigen, routinely used in the clinical practice. Although more studies are required, these circulating markers have the potential to be used as an additional test to improve the diagnosis and treatment decision of high-risk PCa patients. (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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