| Autor: |
Lu DD; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China., Ren JW; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China., Du QQ; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China., Song YJ; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China., Lin SQ; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China., Li X; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China., Li EW; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China., Xie WD; College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China. |
| Abstrakt: |
In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural p -terphenyl glycosides, strepantibin D ( 1 ) and strepantibin E ( 2 ), along with terferol ( 3 ), actinomycin D ( 4 ), actinomycin V ( 5 ) and actinomycin V 0β ( 6 ), were identified from the fermentation medium of a Streptomyces sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D ( 1 ), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural p -terphenyl in this research. Strepantibin D ( 1 ) and terferol ( 3 ) showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins ( 4 - 6 ), especially actinomycin V ( 5 ), displayed remarkable cytotoxicity against breast cancer cells, with IC 50 values ranging from 0.83 nM to 369.90 nM. |
