Synthesis, lipoxygenase inhibition activity and molecular docking of oxamide derivative.

Autor:	Fazal-Ur-Rehman S; Department of Chemistry, University of Karachi, Karachi, Pakistan., Wasim AA; Department of Chemistry, University of Karachi, Karachi, Pakistan., Iqbal S; Department of Chemistry, University of Karachi, Karachi, Pakistan., Khan MA; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan., Lateef M; PCSIR Laboratories Complex, Karachi, Pakistan., Iqbal L; PCSIR Laboratories Complex, Karachi, Pakistan.
Jazyk:	angličtina
Zdroj:	Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2019 May; Vol. 32 (3 (Supplementary)), pp. 1253-1259.
Abstrakt:	In this study, a range of oxamide ligands were synthesized by the reaction of amines with oxalyl chloride in basic medium. Spectroscopic and analytical techniques such as IR, 1H-NMR and ESI-MS techniques were used for characterization of the synthesized oxamides. The synthesized oxamides were screened for Lipoxygenase inhibition. Biological screening revealed that the oxamides possessed good lipoxygenase inhibition activities, whereas, the unsubstituted oxamide did not show any distinct lipoxygenase inhibition activity. Molecular docking studies of the oxamides were also carried out for lipoxygenase inhibition. The results obtained from molecular docking were well correlated with the empirical data.
Databáze:	MEDLINE
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