Risk Factors Associated With New-Onset Diabetes After Liver Transplant: A Case Control Study.

Autor: Terto SV; Federal University of Ceará, Fortaleza, Brazil., Araújo ST; Federal University of Ceará, Fortaleza, Brazil. Electronic address: samila_torquato@hotmail.com., Negreiros FDDS; Federal University of Ceará, Fortaleza, Brazil., Brasil BMBL; Federal University of Ceará, Fortaleza, Brazil., da Cunha GH; Federal University of Ceará, Fortaleza, Brazil., Rodrigues AB; Federal University of Ceará, Fortaleza, Brazil., de Carvalho MMD; Federal University of Ceará, Fortaleza, Brazil., Gadelha DD; Federal University of Ceará, Fortaleza, Brazil., Carioca AAF; University of Fortaleza, Fortaleza, Brazil., Oliveira Fernandes V; Federal University of Ceará, Fortaleza, Brazil., Montenegro Júnior RM; Federal University of Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2019 Jul - Aug; Vol. 51 (6), pp. 1956-1961. Date of Electronic Publication: 2019 Jul 11.
DOI: 10.1016/j.transproceed.2019.04.030
Abstrakt: Background: New-onset diabetes after transplant is a severe complication that can present in liver transplant recipients, negatively impacting quality of life and graft survival. It also contributes to increased risk of infection, cardiovascular disease, and rejection, which are the main causes of death among liver transplant recipients. The aim of the present study was to assess the risk factors associated with new-onset diabetes after transplant.
Method: This was a case control study based on the data from 146 liver transplant patients at a reference hospital. The data from the charts were collected using a 2-part form: Part I (sociodemographic variables) and Part II (clinical variables).
Results: Multiple analysis showed that pre-existing systemic arterial hypertension (odds ratio [OR], 2.65; 95% CI, 1.12-6.28) and the use of sodium mycophenolate associated with tacrolimus (OR, 2.68; 95% CI, 1.02-7.06) increased the risk of new-onset diabetes after transplant. On comparing the anthropometric variables, lipid panel, and blood glucose levels of liver transplant patients with and without diabetes, higher glycemic levels were found in the group with diabetes (P < .001).
Conclusion: Pre-existing systemic arterial hypertension and the associated use of sodium mycophenolate and tacrolimus increased the risk of new-onset diabetes after transplant.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: