Soluble urokinase plasminogen activator receptor in type 1 diabetic children, relation to vascular complications.

Autor: Sherif EM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., El Maksood AAA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Youssef OI; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Salah El-Din NY; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: niron85@hotmail.com., Khater OKM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2019 Sep; Vol. 33 (9), pp. 628-633. Date of Electronic Publication: 2019 Jun 10.
DOI: 10.1016/j.jdiacomp.2019.06.001
Abstrakt: Background: Endothelial dysfunction caused by chronic inflammation is the cornerstone of vascular complications in type 1 Diabetes-Mellitus (T1DM). Soluble Urokinase Plasminogen Activator Receptor (SuPAR) is a novel marker of inflammation and endothelial dysfunction.
Aim: To evaluate SuPAR in T1DM children and correlate it to diabetic vascular complications.
Methods: Seventy T1DM children and 40 matched healthy controls were studied focusing on disease duration, insulin therapy and symptoms of diabetic complications. Blood-pressure, fundus and screening for peripheral-neuropathy were done. Fasting lipid profile, fraction-C of glycosylated hemoglobin (HbA1c%), Urinary albumin excretion (UAE), estimated-glomerular filtration rate (eGFR) and SuPAR were measured. Internal aortic diameter was measured with calculation of aortic distensibility and stiffness index.
Results: Sixteen T1DM patients(22.9%) had peripheral neuropathy, 12(17%) had nephropathy and none had retinopathy. SuPAR was significantly elevated in diabetic nephropathy (p < 0.01) and neuropathy (p < 0.01). Aortic stiffness index was significantly higher (p < 0.01) whereas, aortic strain and distensibility were significantly lower (p < 0.01) in T1DM than controls. SuPAR was significantly correlated to disease duration (p < 0.01), systolic blood pressure (p < 0.01), total cholesterol (p < 0.01), triglycerides (p < 0.01), UAER (p < 0.01) and aortic strain (0.013).
Conclusion: Increased SuPAR early in diabetes might become a useful indicator of developing vascular complications. Further prospective studies are needed to determine the cut-off level of SuPAR for detection of T1DM and its complications.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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