| Autor: |
Odell DW; From the Department of Anesthesiology, University of Utah, Salt Lake City, Utah., Johnson KB, Light AR, Stuart AR, Light KC |
| Jazyk: |
angličtina |
| Zdroj: |
Anesthesia and analgesia [Anesth Analg] 2020 Mar; Vol. 130 (3), pp. e67-e70. |
| DOI: |
10.1213/ANE.0000000000004317 |
| Abstrakt: |
Gene variants may contribute to individual differences in the experience of pain and the efficacy and reward of treatments. We explored gene variation in opioid-naïve and opioid-consuming patients undergoing elective lower extremity total joint replacement. We focused on 3 gene pathways including prostaglandin, gamma-aminobutyric acid (GABA)-ergic reward, and hepatic metabolism pathways. We report that for genes with possible or probable deleterious impact in these 3 pathways, opioid consumers had more gene variants than opioid-naïve patients (median 3 vs 1, P = .0092). We conclude that chronic opiate users may have genetic susceptibility to altered responses in reward/dependency and pain/inflammation pathways. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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