Antioxidant supplementation during illness in dogs: effect on oxidative stress and outcome, an exploratory study.

Autor: Hagen DM; VCA Bay Area Veterinary Specialists & Emergency Hospital, San Leandro, California, 94578, USA., Ekena JL; Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA., Geesaman BM; Carolina Veterinary Specialist, Winston-Salem, North Carolina, 27103, USA., Viviano KR; Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.
Jazyk: angličtina
Zdroj: The Journal of small animal practice [J Small Anim Pract] 2019 Sep; Vol. 60 (9), pp. 543-550. Date of Electronic Publication: 2019 Jul 10.
DOI: 10.1111/jsap.13050
Abstrakt: Objectives: To assess whether combination antioxidant supplementation for 30 days in systemically ill dogs alters antioxidant status, degree of lipid peroxidation, clinical score and survival.
Materials and Methods: Forty client-owned systemically-ill hospitalised dogs were eligible for inclusion. Dogs were randomised to no supplementation (NS; n=19) or supplementation with N-acetylcysteine/S-adenosylmethionine/silybin and vitamin E (AS; n=20) for 30 days. Clinical score and oxidative biomarkers including glutathione, cysteine, vitamin E, selenium and urine isoprostanes/creatinine (F 2 -IsoPs/Cr) were determined on days 0 and 30. Glutathione, cysteine, vitamin E and urine F 2 -IsoPs/Cr were quantified by high-performance liquid chromatography, and selenium concentrations determined using atomic absorption spectroscopy.
Results: Thirty-two dogs completed the study (NS, n=16; AS, n=16). Vitamin E concentrations were significantly greater in the supplemented compared to the non-supplemented group. No other markers of oxidative stress significantly changed with supplementation. There was no difference in Day 30 clinical scores or survival between the two groups.
Clinical Significance: In this population of systemically-ill hospitalised dogs, combination antioxidant supplementation did not alter redox state or clinical outcome.
(© 2019 British Small Animal Veterinary Association.)
Databáze: MEDLINE
Externí odkaz: