Toxoplasmosis and mental disorders in the Russian Federation (with special reference to schizophrenia).

Autor: Stepanova EV; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Kondrashin AV; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Sergiev VP; Department of Tropical Medicine and Parasitic Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Morozova LF; Department of Tropical Medicine and Parasitic Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Turbabina NA; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Maksimova MS; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Romanov DV; Department of Psychiatry & Psychosomatics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.; Mental Health Research Center, Moscow, Russian Federation., Kinkulkina MA; Department of Psychiatry & Substance Addiction, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Lazareva AV; Department of Psychiatry & Substance Addiction, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation., Morozov EN; Department of Tropical Medicine and Parasitic Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.; Department of Tropical, Parasitic Diseases and Disinfectology, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 Jul 10; Vol. 14 (7), pp. e0219454. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0219454
Abstrakt: The association of latent toxoplasmosis with mental disorders in general and with schizophrenia in particular was noticed in the mid-1950s. In subsequent years, the role of Toxoplasma gondii was established based on its ability to survive for long periods of time in the nerve cells of the brain. The acute manifestations of the infection include psychopathic symptoms resembling those of schizophrenia. In the former USSR, and in other parts of the world, a number of studies were performed with respect to the association of latent toxoplasmosis and schizophrenia. However, with the dissolution of the USSR at the beginning of the 1990s, studies on the subject were halted due to financial problems and have resumed only recently. The reasons for the resumption of such studies in contemporary Russia are related to the progressively increasing incidence of schizophrenia over the last 25-30 years in the country. According to official data, approximately 550 000 persons reported suffering from the disease in 2014. There are reasons to believe that this is only a fraction of the real burden of the disease. Economically, it cost the state no less than approximately US $10 billion. The purpose of the study was to identify the level of toxoplasmosis seroprevalence in patients with verified diagnoses of schizophrenia in comparison to healthy people in Moscow City and in the Moscow region. A total of 155 persons constituted the patients group and 152 healthy people were in the control group. An integrated approach to the diagnosis and comparison of data from the entire spectrum of serological markers of infection was used, including the detection of specific IgM and the determination of IgG concentrations. It was found that among persons with neuropsychiatric disorders, the incidence of cases with latent toxoplasmosis was higher than in the control group. The effect of toxoplasmosis was significant and similar for men and women. Further statistical analyses revealed that among patients with a diagnosis of schizophrenia, the incidence of latent toxoplasmosis was significantly higher than in the control group. These data are in agreement with the results of similar studies in other countries.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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