Diabetic neuropathy research: from mouse models to targets for treatment.

Autor:	Pham VM; Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan; Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore., Matsumura S; Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan., Katano T; Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan., Funatsu N; Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan., Ito S; Department of Medical Chemistry, Kansai Medical University, Hirakata; Department of Anesthesiology, Osaka Medical College, Takatsuki, Osaka, Japan.
Jazyk:	angličtina
Zdroj:	Neural regeneration research [Neural Regen Res] 2019 Nov; Vol. 14 (11), pp. 1870-1879.
DOI:	10.4103/1673-5374.259603
Abstrakt:	Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment. Competing Interests: None
Databáze:	MEDLINE
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