Ag Nanoparticles/α-Ag 2 WO 4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents.

Autor: Assis M; CDMF, LIEC, Chemistry Department of the Federal University of São Carlos - (UFSCar), P.O. Box 676, 13565-905, São Carlos, SP, Brazil., Robeldo T; LIA, Laboratory of Applied Immunology, Department of Genetics and Evolution, Federal University of São Carlos - (UFSCar), São Carlos, Brazil., Foggi CC; CDMF, LIEC, Chemistry Department of the Federal University of São Carlos - (UFSCar), P.O. Box 676, 13565-905, São Carlos, SP, Brazil., Kubo AM; CDMF, LIEC, Chemistry Department of the Federal University of São Carlos - (UFSCar), P.O. Box 676, 13565-905, São Carlos, SP, Brazil., Mínguez-Vega G; GROC∙UJI, Institut de Noves Tecnologies de la Imatge (INIT, University Jaume I (UJI), Castelló, 12071, Spain., Condoncillo E; Department of Inorganic and Organic Chemistry, University Jaume I (UJI), Castelló, 12071, Spain., Beltran-Mir H; Department of Inorganic and Organic Chemistry, University Jaume I (UJI), Castelló, 12071, Spain., Torres-Mendieta R; Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17, Liberec, Czech Republic., Andrés J; Department of Analytical and Physical Chemistry, University Jaume I (UJI), Castelló, 12071, Spain., Oliva M; Department of Analytical and Physical Chemistry, University Jaume I (UJI), Castelló, 12071, Spain., Vergani CE; São Paulo State University (UNESP), Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil., Barbugli PA; São Paulo State University (UNESP), Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil., Camargo ER; CDMF, LIEC, Chemistry Department of the Federal University of São Carlos - (UFSCar), P.O. Box 676, 13565-905, São Carlos, SP, Brazil., Borra RC; LIA, Laboratory of Applied Immunology, Department of Genetics and Evolution, Federal University of São Carlos - (UFSCar), São Carlos, Brazil., Longo E; CDMF, LIEC, Chemistry Department of the Federal University of São Carlos - (UFSCar), P.O. Box 676, 13565-905, São Carlos, SP, Brazil. elson.liec@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2019 Jul 09; Vol. 9 (1), pp. 9927. Date of Electronic Publication: 2019 Jul 09.
DOI: 10.1038/s41598-019-46159-y
Abstrakt: The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag 2 WO 4 , irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag 2 WO 4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag 2 WO 4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected.
Databáze: MEDLINE
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