Optoacoustic Imaging and Gray-Scale US Features of Breast Cancers: Correlation with Molecular Subtypes.

Autor:	Dogan BE; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Menezes GLG; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Butler RS; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Neuschler EI; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Aitchison R; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Lavin PT; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Tucker FL; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Grobmyer SR; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Otto PM; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.)., Stavros AT; From the Department of Diagnostic Radiology, The University of Texas Southwestern Medical Center, 2201 Inwood Rd, Dallas, TX 75390-8585 (B.E.D.); Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX (G.L.G.M., P.M.O., A.T.S.); Seno Medical Instruments, San Antonio, TX (G.L.G.M., A.T.S.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (R.S.B.); Department of Radiology, Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL (E.I.N.); Boston Biostatistics Research Foundation, Boston, MA (R.A., P.T.L); Virginia Biomedical Laboratories, LLC, Wirtz, VA (F.L.T.); and Department of Surgical Oncology, Cleveland Clinic, Cleveland, OH (S.R.G.).
Jazyk:	angličtina
Zdroj:	Radiology [Radiology] 2019 Sep; Vol. 292 (3), pp. 564-572. Date of Electronic Publication: 2019 Jul 09.
DOI:	10.1148/radiol.2019182071
Abstrakt:	Background Optoacoustic imaging can assess tumor hypoxia coregistered with US gray-scale images. The combination of optoacoustic imaging and US may have a role in distinguishing breast cancer molecular subtypes. Purpose To investigate whether optoacoustic US feature scores correlate with breast cancer molecular subtypes. Materials and Methods A total of 1972 women (with a total of 2055 breast masses) underwent prebiopsy optoacoustic US in a prospective multi-institutional study between December 2012 and September 2015. Seven readers blinded to pathologic diagnosis scored gray-scale US and optoacoustic US features of the known cancers. Optoacoustic US features within (internal) and outside of the tumor boundary (external) were scored. Immunohistochemistry findings were obtained from pathology reports. Multinomial logistic regression analysis was used to fit the US scores, adding optoacoustic US features to the model to investigate the incremental benefit of each feature. Kruskal-Wallis tests were used to analyze the relationship between molecular subtypes and feature scores. Results Among 653 invasive cancers identified in 629 women, a total of 532 cancers in 519 women, all of which had molecular markers available, were included in the analysis. Mean age ± standard deviation was 57.9 years ± 12.6. Mean total external optoacoustic US feature scores of luminal (A and B) breast cancers were higher (9.9 vs 8.8; P < .05) and total internal scores were lower (6.8 vs 7.7; P < .001) than those of triple-negative and human epidermal growth factor receptor 2-positive (HER2+) cancers. A multinomial logistic regression model showed that optoacoustic internal vessel (odds ratio [OR], 0.6; 95% confidence interval [CI]: 0.5, 0.8; P = .002), optoacoustic internal blush (OR, 0.7; 95% CI: 0.5, 0.9; P = .02), and optoacoustic internal hemoglobin (OR, 0.6; 95% CI: 0.5, 0.8; P = .001) were associated with classification of luminal versus triple-negative and HER2+ cancer subtypes. Conclusion Combined optoacoustic US imaging and gray-scale US features may help distinguish luminal breast cancers from triple-negative and human epidermal growth factor receptor 2-positive cancers. © RSNA, 2019 Online supplemental material is available for this article. See also the editorial by Mann in this issue.
Databáze:	MEDLINE
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