| Autor: |
Saputro ID; Soetomo General Academic Hospital, Surabaya, Indonesia., Putra ON; Hang Tuah University, Surabaya, Indonesia., Pebrianton H; Mintohardjo Hospital, Jakarta, Indonesia., Suharjono; Airlangga University, Surabaya, Indonesia. |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of burns and fire disasters [Ann Burns Fire Disasters] 2019 Mar 31; Vol. 32 (1), pp. 70-76. |
| Abstrakt: |
Severe burn injuries are associated with systemic inflammation or even sepsis. A beneficial effect of probiotics on burn patients is reported by regulating the function of the intestinal barrier and reducing inflammation. Immunoglobulin A (IgA) acts as an anti-inflammation antibody, and interleukin 6 (IL-6) as a pro-inflammatory mediator, released extensively in burns. The aim of this study was to investigate the effect of single and mixed strain probiotics on the level of IgA and IL-6 in severe burn patients. A randomized double-blind trial was conducted in the burn centre of the Dr. Soetomo Hospital. Severe burn patients with more than 20% total body surface area burned were randomized into two groups. Group one received a single strain and the second group received mixed strain probiotics, once daily for fourteen days. Serum levels of IgA and IL-6 were measured on day 4 post burn injury (before treatment) and day 19 (after treatment). Seventeen burn patients were enrolled in this study. IgA increased significantly from 1.01±0.67 to 1.89±0.98 mg/mL (p<0.001) in the single strain group, and 0.96±0.48 to 2.10±1.09 mg/mL (p=0.025) in the mixed strain group by paired t-test. There was no significant decrease in IL-6 in either group. No significant differences between the two groups were observed for IgA or IL-6. Administration of single and mixed strain probiotics increased IgA level, while there was no decrease in IL-6 level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
