Cold Atmospheric Plasma as an Adjunct to Immunotherapy for Glioblastoma Multiforme.

Autor: Almeida ND; The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA., Klein AL; The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia, USA., Hogan EA; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA. Electronic address: eahogan13@gmail.com., Terhaar SJ; The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA., Kedda J; The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA., Uppal P; The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA., Sack K; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA., Keidar M; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia, USA., Sherman JH; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2019 Oct; Vol. 130, pp. 369-376. Date of Electronic Publication: 2019 Jul 05.
DOI: 10.1016/j.wneu.2019.06.209
Abstrakt: Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in adults. GBM carries a dismal prognosis because of its proliferative, invasive, and angiogenic capabilities and because of its ability to downregulate the immune system. Immune-based therapies under investigation for GBM have been unsuccessful in vivo because of this downregulation. Cold atmospheric plasma (CAP) is a high-energy state of matter that can be applied directly or indirectly to tumor tissue to serve as an adjunct to immunotherapy in the treatment of GBM because it upregulates the immune system by the induction of reactive oxygen species. CAP has the potential to improve the efficacy of existing and investigative immunotherapies for GBM.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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